Gene ZPB1 turns on and off and is crucial in the spread of breast cancer. Scientists at the Albert Einstein College of Medicine have studied the behavior of this gene and now understand what causes the gene to turn on and off. This new understanding can help them not only better predict whether breast cancer will metastasize but will also enable future drug treatments to target the desired behavior of the gene.
One of ZPB1’s discoverer’s and the lead of the study, Dr. Robert Singer says that ZPB1 is typically silent in adult tissues, however the gene is reactivated in colorectal, breast and non-small cell lung cancers. The study identifies that when ZPB1 is prevented from binding to protein beta-catenin, it is silenced. It also shows that when the gene is silenced, cancer cells are better able to mobilize and migrate.
For more information please visit http://www.breakthroughdigest.com/cancer-treatment/breast-cancer/scientists-identify-gene-in-breast-cancer-pathway/.